Wednesday, March 25, 2009

Metformin



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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature advance online publication 04 March 2009. doi:10.1038/nature07813 Authors: Carles Cantó, Zachary Gerhart-Hines, Jerome N. Feige, Marie Lagouge, Lilia Noriega, Jill C. Milne, Peter J. Elliott, Pere Puigserv...

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Two years ago, University of Wisconsin-Madison scientists reported they had suppressed epileptic seizures in rats by giving them a glycolytic-inhibitor, inhibiting the brain's ability to turn sugar into excess energy and blocking the expression of seizure-related genes. A1c up to 7.2, a big time indicator of the recent noncompliance-fest I've had. As I've been mentioning, that is over, but it's always going to be riding on my back. It's definitely easier to pretend you don't have this fucking disease than to admit it and deal with it 24/7. Okay, that didn't quite c ...

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